Background: Primary Hyperoxaluria Type 1 (PH1) is an inborn error of metabolism caused by mutations in the AGXT gene, which encodes for the hepatocyte-specific enzyme alanine: glyoxylate aminotransferase (AGT).AGT catalyzes the conversion of glyoxylate to glycine in the peroxisome and prevents the build-up of oxalate which occurs in PH1.This causes
Brief Biosketch Prof.(Dr) Md Iqbal Alam working as head of the Department of Physiology at HIMSR, Jamia Hamdard, New Delhi.He did his PhD from the University of Calcutta.He was awarded Best Poster in International Conference on Recent Advances in Food fortification with emphasis on Vitamin D in human health, 2018 at Jamia Hamdard, New Delhi., First
Abstract Background Trehalose is a functional disaccharide that has anti-metabolic activities such as suppression of adipocyte hypertrophy in mice and alleviation of impaired glucose tolerance in humans.Trehalase hydrolyzes trehalose in the small intestine into two glucose molecules.In this study, we investigated whether trehalose can suppress adip
Activation-induced Cytidine Deaminase (AID) is an essential regulator of B cell diversification, but its full range of action has until recently been an enigma.Based on homology, it was originally proposed to be an RNA-editing enzyme, but so far, no RNA substrates are known.Rather, it functions by deaminating cytidine, and in this manner, coupled w
The transmission and prevalence of Human Immunodeficiency Virus (HIV) among those employed as sex trade workers (STW) is a major public health concern.The present study describes the self-reported responses of 340 STW, at-risk for contracting HIV.The participants were recruited by selective targeting between 2009 and 2010 from within the Saskatoon